Structural architecture and functional evolution of Wnts.

ABSTRACT: The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds.

SUBMITTER: Bazan JF 

PROVIDER: S-EPMC3458506 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature