Global identification of transcriptional regulators of pluripotency and differentiation in embryonic stem cells.

ABSTRACT: Human embryonic stem cells (hESCs) hold great promise for regenerative medicine because they can undergo unlimited self-renewal and retain the capability to differentiate into all cell types in the body. Although numerous genes/proteins such as Oct4 and Gata6 have been identified to play critical regulatory roles in self-renewal and differentiation of hESC, the majority of the regulators in these cellular processes and more importantly how these regulators co-operate with each other and/or with epigenetic modifications are still largely unknown. We propose here a systematic approach to integrate genomic and epigenomic data for identification of direct regulatory interactions. This approach allows reconstruction of cell-type-specific transcription networks in embryonic stem cells (ESCs) and

SUBMITTER: Won KJ 

PROVIDER: S-EPMC3458541 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature