MyoD regulates p57kip2 expression by interacting with a distant cis-element and modifying a higher order chromatin structure.

ABSTRACT: The bHLH transcription factor MyoD, the prototypical master regulator of differentiation, directs a complex program of gene expression during skeletal myogenesis. The up-regulation of the cdk inhibitor p57kip2 plays a critical role in coordinating differentiation and growth arrest during muscle development, as well as in other tissues. p57kip2 displays a highly specific expression pattern and is subject to a complex epigenetic control driving the imprinting of the paternal allele. However, the regulatory mechanisms governing its expression during development are still poorly understood. We have identified an unexpected mechanism by which MyoD regulates p57kip2 transcription in differentiating muscle cells. We show that the induction of p57kip2 requires MyoD binding to a long-distance eleme

SUBMITTER: Busanello A 

PROVIDER: S-EPMC3458561 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature