A distinct regulatory sequence is essential for the expression of a subset of nle genes in attaching and effacing Escherichia coli.

ABSTRACT: Enteropathogenic Escherichia coli uses a type III secretion system (T3SS), encoded in the locus of enterocyte effacement (LEE) pathogenicity island, to translocate a wide repertoire of effector proteins into the host cell in order to subvert cell signaling cascades and promote bacterial colonization and survival. Genes encoding type III-secreted effectors are located in the LEE and scattered throughout the chromosome. While LEE gene regulation is better understood, the conditions and factors involved in the expression of effectors encoded outside the LEE are just starting to be elucidated. Here, we identified a highly conserved sequence containing a 13-bp inverted repeat (IR), located upstream of a subset of genes coding for different non-LEE-encoded effectors in A/E pathogens. Site-direct

SUBMITTER: Garcia-Angulo VA 

PROVIDER: S-EPMC3458664 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature