Organocatalytic asymmetric allylic amination of Morita-Baylis-Hillman carbonates of isatins.

ABSTRACT: The investigation of a Lewis base catalyzed asymmetric allylic amination of Morita-Baylis-Hillman carbonates derived from isatins afforded an electrophilic pathway to access multifunctional oxindoles bearing a C3-quaternary stereocenter, provided with good to excellent enantioselectivity (up to 94% ee) and in high yields (up to 97%).

SUBMITTER: Zhang H 

PROVIDER: S-EPMC3458744 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature