Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations.

ABSTRACT: Sequential cycloisomerizations of diynyl o-benzaldehyde substrates to access novel polycyclic cyclopropanes are reported. The reaction sequence involves initial Cu(I)-mediated cycloisomerization/nucleophilic addition to an isochromene followed by diastereoselective Pt(II)-catalyzed enyne cycloisomerization.

SUBMITTER: Leng B 

PROVIDER: S-EPMC3458758 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature