Postoperative use of non-steroidal anti-inflammatory drugs in patients with anastomotic leakage requiring reoperation after colorectal resection: cohort study based on prospective data.

ABSTRACT:

Objectives

To evaluate the effect of postoperative use of non-steroidal anti-inflammatory drugs (NSAIDs) on anastomotic leakage requiring reoperation after colorectal resection.

Design

Cohort study based on data from a prospective clinical database and electronically registered medical records.

Setting

Six major colorectal centres in eastern Denmark.

Participants

2766 patients (1441 (52%) men) undergoing elective operation for colorectal cancer with colonic or rectal resection and primary anastomosis between 1 January 2006 and 31 December 2009. Median age was 70 years (interquartile range 62-77).

Intervention

Postoperative use of NSAID (defined as at least two days of NSAID treatment in the first seven days after surgery).

Main outcome measures

Fr

SUBMITTER: Klein M 

PROVIDER: S-EPMC3458793 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature