Association between CD14 gene C-260T polymorphism and inflammatory bowel disease: a meta-analysis.

ABSTRACT:

Background

The gene encoding CD14 has been proposed as an IBD-susceptibility gene with its polymorphism C-260T being widely evaluated, yet with conflicting results. The aim of this study was to investigate the association between this polymorphism and IBD by conducting a meta-analysis.

Methodology/principal findings

Seventeen articles met the inclusion criteria, which included a total of 18 case-control studies, including 1900 ulcerative colitis (UC) cases, 2535 Crohn's disease (CD) cases, and 4004 controls. Data were analyzed using STATA software. Overall, association between C-260T polymorphism and increased UC risk was significant in allelic comparison (odds ratio [OR]  =1.21, 95% confidence interval [CI]: 1.02-1.43; P=0.027), homozygote model (OR  =1.44, 95% CI: 1.03-2.0

SUBMITTER: Wang Z 

PROVIDER: S-EPMC3458839 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature