Porcine tissue-specific regulatory networks derived from meta-analysis of the transcriptome.

ABSTRACT: The processes that drive tissue identity and differentiation remain unclear for most tissue types. So are the gene networks and transcription factors (TF) responsible for the differential structure and function of each particular tissue, and this is particularly true for non model species with incomplete genomic resources. To better understand the regulation of genes responsible for tissue identity in pigs, we have inferred regulatory networks from a meta-analysis of 20 gene expression studies spanning 480 Porcine Affymetrix chips for 134 experimental conditions on 27 distinct tissues. We developed a mixed-model normalization approach with a covariance structure that accommodated the disparity in the origin of the individual studies, and obtained the normalized expression of 12,320 genes a

SUBMITTER: Perez-Montarelo D 

PROVIDER: S-EPMC3458843 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature