Rab GTPase mediated procollagen trafficking in ascorbic acid stimulated osteoblasts.

ABSTRACT: Despite advances in investigating functional aspects of osteoblast (OB) differentiation, especially studies on how bone proteins are deposited and mineralized, there has been little research on the intracellular trafficking of bone proteins during OB differentiation. Collagen synthesis and secretion is the major function of OBs and is markedly up-regulated upon ascorbic acid (AA) stimulation, significantly more so than in fibroblast cells. Understanding the mechanism by which collagen is mobilized in specialized OB cells is important for both basic cell biology and diseases involving defects in bone protein secretion and deposition. Protein trafficking along the exocytic and endocytic pathways is aided by many molecules, with Rab GTPases being master regulators of vesicle targeting. In thi

SUBMITTER: Nabavi N 

PROVIDER: S-EPMC3458846 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature