Further evidence of subphenotype association with systemic lupus erythematosus susceptibility loci: a European cases only study.

ABSTRACT:

Introduction

Systemic Lupus Erythematosus (SLE) shows a spectrum of clinical manifestations that complicate its diagnosis, treatment and research. This variability is likely related with environmental exposures and genetic factors among which known SLE susceptibility loci are prime candidates. The first published analyses seem to indicate that this is the case for some of them, but results are still inconclusive and we aimed to further explore this question.

Methods

European SLE patients, 1444, recruited at 17 centres from 10 countries were analyzed. Genotypes for 26 SLE associated SNPs were compared between patients with and without each of 11 clinical features: ten of the American College of Rheumatology (ACR) classification criteria (except ANAs) and age of disease onset.

SUBMITTER: Alonso-Perez E 

PROVIDER: S-EPMC3458859 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature