Exploring the evolution of protein function in Archaea.

ABSTRACT:

Background

Despite recent progress in studies of the evolution of protein function, the questions what were the first functional protein domains and what were their basic building blocks remain unresolved. Previously, we introduced the concept of elementary functional loops (EFLs), which are the functional units of enzymes that provide elementary reactions in biochemical transformations. They are presumably descendants of primordial catalytic peptides.

Results

We analyzed distant evolutionary connections between protein functions in Archaea based on the EFLs comprising them. We show examples of the involvement of EFLs in new functional domains, as well as reutilization of EFLs and functional domains in building multidomain structures and protein complexes.

Conclusions

SUBMITTER: Goncearenco A 

PROVIDER: S-EPMC3458885 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature