Development of the multi-attribute Adolescent Health Utility Measure (AHUM).

ABSTRACT:

Objective

Obtain utilities (preferences) for a generalizable set of health states experienced by older children and adolescents who receive therapy for chronic health conditions.

Methods

A health state classification system, the Adolescent Health Utility Measure (AHUM), was developed based on generic health status measures and input from children with Hunter syndrome and their caregivers. The AHUM contains six dimensions with 4-7 severity levels: self-care, pain, mobility, strenuous activities, self-image, and health perceptions. Using the time trade off (TTO) approach, a UK population sample provided utilities for 62 of 16,800 AHUM states. A mixed effects model was used to estimate utilities for the AHUM states. The AHUM was applied to trial NCT00069641 of idursulfase for H

SUBMITTER: Beusterien KM 

PROVIDER: S-EPMC3458914 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature