Insights into the evolution of sorbitol metabolism: phylogenetic analysis of SDR196C family.

ABSTRACT:

Background

Short chain dehydrogenases/reductases (SDR) are NAD(P)(H)-dependent oxidoreductases with a highly conserved 3D structure and of an early origin, which has allowed them to diverge into several families and enzymatic activities. The SDR196C family (http://www.sdr-enzymes.org) groups bacterial sorbitol dehydrogenases (SDH), which are of great industrial interest. In this study, we examine the phylogenetic relationship between the members of this family, and based on the findings and some sequence conserved blocks, a new and a more accurate classification is proposed.

Results

The distribution of the 66 bacterial SDH species analyzed was limited to Gram-negative bacteria. Six different bacterial families were found, encompassing α-, β- and γ-proteobacteria. This broad

SUBMITTER: Sola-Carvajal A 

PROVIDER: S-EPMC3458964 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature