Association of cytochrome P450 genetic polymorphisms with neoadjuvant chemotherapy efficacy in breast cancer patients.

ABSTRACT:

Background

The enzymes of the cytochrome P450 family (CYPs) play an important role in the metabolism of a great variety of anticancer agents; therefore, polymorphisms in genes encoding for metabolizing enzymes and drugs transporters can affect drug efficacy and toxicity.

Methods

The genetic polymorphisms of cytochrome P450 were studied in 395 patients with breast cancer by RLFP analysis.

Results

Here, we studied the association of functionally significant variant alleles of CYP3A4, CYP3A5, CYP2B6, CYP2C8, CYP2C9 and CYP2C19 with the clinical response to neoadjuvant chemotherapy in breast cancer patients. A significant correlation was observed between the CYP2C9*2 polymorphism and chemotherapy resistance (OR = 4.64; CI 95% = 1.01 - 20.91), as well as between CYP2C9*2 h

SUBMITTER: Seredina TA 

PROVIDER: S-EPMC3458973 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature