Genetic and lifestyle influence on telomere length and subsequent risk of colon cancer in a case control study.

ABSTRACT:

Background

Telomeres cap the ends of chromosomes and help maintain genomic stability and integrity. Telomere length (TL) has been linked to a number of diseases, including a variety of cancers; however, the association between TL and risk for colorectal cancer is unclear.

Methods

We investigate the association between genetic, diet, and lifestyle factors and TL and the association between TL and colorectal cancer using data from a population-based case-control study of colon (249 cases and 371 controls) and rectal cancer (276 cases and 372 controls) conducted in Utah. DNA samples came from immortalized cell lines for colon cancer and directly from whole blood for rectal cancer. We genotyped 11 single nucleotide polymorphisms in five genes associated with telomeres, TERT, MEN

SUBMITTER: Pellatt AJ 

PROVIDER: S-EPMC3459220 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature