US IRBs confronting research in the developing world.

ABSTRACT:

Unlabelled

Increasingly, US-sponsored research is carried out in developing countries, but how US Institutional Review Boards (IRBs) approach the challenges they then face is unclear.

Methods

I conducted in-depth interviews of about 2 hours each, with 46 IRB chairs, directors, administrators and members. I contacted the leadership of 60 IRBs in the United States (US) (every fourth one in the list of the top 240 institutions by National Institutes of Health (NIH) funding), and interviewed IRB leaders from 34 (55%).

Results

US IRBs face ethical and logistical challenges in interpreting and applying principles and regulations in developing countries, given economic and health disparities, and limited contextual knowledge. These IRBs perceive wide variations in developing

SUBMITTER: Klitzman RL 

PROVIDER: S-EPMC3459236 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature