Associations of body mass index and insulin resistance with leptin, adiponectin, and the leptin-to-adiponectin ratio across ethnic groups: the Multi-Ethnic Study of Atherosclerosis (MESA).

ABSTRACT:

Purpose

Associations of adiponectin and leptin and their ratio with body mass index (BMI) and homeostasis model assessment of insulin resistance (HOMA-IR) have been investigated in different ethnic groups but variability in both assays and statistical methods have made cross-study comparisons difficult. We examined associations among these variables across four ethnic groups in a single study.

Methods

Adiponectin and leptin were measured in a subset of participants from the Multi-Ethnic Study of Atherosclerosis study. We calculated associations (using both partial correlations and adjusted linear regression) in each ethnic group and then compared the magnitude of these associations across groups.

Results

After we excluded individuals with type 2 diabetes, there were 7

SUBMITTER: Rasmussen-Torvik LJ 

PROVIDER: S-EPMC3459265 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature