A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern.

ABSTRACT:

Background

The early repolarization pattern (ERP) is common and associated with risk of sudden cardiac death. ERP is heritable, and mutations have been described in syndromatic cases.

Objective

To conduct a meta-analysis of genome-wide association studies to identify common genetic variants influencing ERP.

Methods

We ascertained ERP on the basis of electrocardiograms in 3 large community-based cohorts from Europe and the United States: the Framingham Heart Study, the Health 2000 Study, and the KORA F4 Study. We analyzed genome-wide association studies in participants with and without ERP by logistic regression assuming an additive genetic model and meta-analyzed individual cohort results. We then sought to strengthen support for findings that reached P ≤ 1 × 10(-5) i

SUBMITTER: Sinner MF 

PROVIDER: S-EPMC3459269 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature