High-resolution whole-genome analysis of skull base chordomas implicates FHIT loss in chordoma pathogenesis.

ABSTRACT: Chordoma is a rare tumor arising in the sacrum, clivus, or vertebrae. It is often not completely resectable and shows a high incidence of recurrence and progression with shortened patient survival and impaired quality of life. Chemotherapeutic options are limited to investigational therapies at present. Therefore, adjuvant therapy for control of tumor recurrence and progression is of great interest, especially in skull base lesions where complete tumor resection is often not possible because of the proximity of cranial nerves. To understand the extent of genetic instability and associated chromosomal and gene losses or gains in skull base chordoma, we undertook whole-genome single-nucleotide polymorphism microarray analysis of flash frozen surgical chordoma specimens, 21 from the clivus an

SUBMITTER: Diaz RJ 

PROVIDER: S-EPMC3459274 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature