MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer.

ABSTRACT: Several microRNAs (miRNAs) are known to be deregulated in colon cancer, but the mechanisms behind their potential involvement on proliferation and tumor cell survival are unclear. The present study aimed to identify miRNAs with functional implications for development of colon cancer. The cell proliferation and apoptosis were examined following perturbations of miRNA levels by employing a comprehensive miRNA library screen. miRNAs nominated for relevance to colon cancer were validated on expression and functional levels. By integrating the effect of miRNA up-regulation with the endogenous miRNA expression levels within the HT29, HCT116, and SW480 colon cancer cell lines, we identified miRNAs controlling cell proliferation (n = 53) and apoptosis (n = 93). From these functionally nominated mi

SUBMITTER: Cekaite L 

PROVIDER: S-EPMC3459282 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature