Palladium-catalyzed 1,1-difunctionalization of ethylene.

ABSTRACT: The 1,1-difunctionalization of ethylene, with aryl/vinyl/heteroaryl transmetalating agents and vinyl electrophiles, is reported. The reaction is high-yielding under a low pressure of ethylene, and regioselectivity is generally high for the 1,1-disubstituted product. The process is highlighted by the use of heteroaromatic cross-coupling reagents, which have not been competent reaction partners in previously reported efforts.

SUBMITTER: Saini V 

PROVIDER: S-EPMC3459322 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature