Palladium(II)-catalyzed enantio- and diastereoselective synthesis of pyrrolidine derivatives.

ABSTRACT: A palladium-catalyzed enantio- and diastereoselective synthesis of pyrrolidine derivatives is described. Initial intramolecular nucleopalladation of the tethered protected amine forms the pyrrolidine moiety and a quinone methide intermediate. A second nucleophile adds intermolecularly to afford diverse products in high enantio- and diastereoselectivity.

SUBMITTER: Jana R 

PROVIDER: S-EPMC3459323 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature