Serum proteome changes in dengue virus-infected patients from a dengue-endemic area of India: towards new molecular targets?

ABSTRACT: The global burden of dengue continues to worsen, specifically in tropical and subtropical countries, and has evolved as a major public health problem. We investigated the changes in serum proteome in dengue fever (DF) patients from a dengue-endemic area of India to obtain mechanistic insights about the disease pathogenesis, the host immune response, and identification of potential serum protein biomarkers of this infectious disease. In this study, serum samples from DF patients, healthy subjects, and patients with falciparum malaria (an infectious disease control) were investigated by 2D-DIGE in combination with MALDI-TOF/TOF MS. The findings were validated with Western blotting. Functional clustering of the identified proteins was performed using PANTHER and DAVID tools. Compared to the h

SUBMITTER: Ray S 

PROVIDER: S-EPMC3459427 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature