Association of a genetic risk score with prevalent and incident myocardial infarction in subjects undergoing coronary angiography.

ABSTRACT:

Background

Genome-wide association studies have identified multiple variants associating with coronary artery disease (CAD) and myocardial infarction (MI). Whether a combined genetic risk score (GRS) is associated with prevalent and incident MI in high-risk subjects remains to be established.

Methods and results

In subjects undergoing cardiac catheterization (n=2597), we identified cases with a history of MI onset at age <70 years and controls ≥70 years without prior MI and followed them for incident MI and death. Genotyping was performed for 11 established CAD/MI variants, and a GRS was calculated based on average number of risk alleles carried at each locus weighted by effect size. Replication of association findings was sought in an independent angiographic cohort (n=2702

SUBMITTER: Patel RS 

PROVIDER: S-EPMC3459582 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature