Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study.

ABSTRACT:

Background

The Toll-like receptor proteins are important in host defense and initiation of the innate and adaptive immune responses. A number of studies have identified associations between genetic variation in the Toll-like receptor genes and allergic disorders such as asthma and allergic rhinitis. The present study aim to search for genetic variation associated with allergic rhinitis in the Toll-like receptor genes.

Methods

A first association analysis genotyped 73 SNPs in 182 cases and 378 controls from a Swedish population. Based on these results an additional 24 SNPs were analyzed in one Swedish population with 352 cases and 709 controls and one Chinese population with 948 cases and 580 controls.

Results

The first association analysis identified 4 allergic rhinit

SUBMITTER: Nilsson D 

PROVIDER: S-EPMC3459792 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature