Tissue-specific functional networks for prioritizing phenotype and disease genes.

ABSTRACT: Integrated analyses of functional genomics data have enormous potential for identifying phenotype-associated genes. Tissue-specificity is an important aspect of many genetic diseases, reflecting the potentially different roles of proteins and pathways in diverse cell lineages. Accounting for tissue specificity in global integration of functional genomics data is challenging, as "functionality" and "functional relationships" are often not resolved for specific tissue types. We address this challenge by generating tissue-specific functional networks, which can effectively represent the diversity of protein function for more accurate identification of phenotype-associated genes in the laboratory mouse. Specifically, we created 107 tissue-specific functional relationship networks through integ

SUBMITTER: Guan Y 

PROVIDER: S-EPMC3459891 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature