Determinants of human adipose tissue gene expression: impact of diet, sex, metabolic status, and cis genetic regulation.

ABSTRACT: Weight control diets favorably affect parameters of the metabolic syndrome and delay the onset of diabetic complications. The adaptations occurring in adipose tissue (AT) are likely to have a profound impact on the whole body response as AT is a key target of dietary intervention. Identification of environmental and individual factors controlling AT adaptation is therefore essential. Here, expression of 271 transcripts, selected for regulation according to obesity and weight changes, was determined in 515 individuals before, after 8-week low-calorie diet-induced weight loss, and after 26-week ad libitum weight maintenance diets. For 175 genes, opposite regulation was observed during calorie restriction and weight maintenance phases, independently of variations in body weight. Metabolism an

SUBMITTER: Viguerie N 

PROVIDER: S-EPMC3459935 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature