Pharmacokinetics of cyclosporin--a microemulsion in children with idiopathic nephrotic syndrome.

ABSTRACT:

Objective

We present a prospective study of a microemulsion of cyclosporin to treat idiopathic nephrotic syndrome in ten children with normal renal function who presented cyclosporin trough levels between 50 and 150 ng/ml and achieved complete remission with cyclosporin. To compare the pharmacokinetic parameters of cyclosporin in idiopathic nephrotic syndrome during remission and relapse of the nephrotic state.

Method

The pharmacokinetic profile of cyclosporin was evaluated with the 12-hour area under the time-concentration curve (auc0-12) using seven time-point samples. This procedure was performed on each patient during remission and relapse with the same cyclosporin dose in mg/kg/day. The 12-hour area under the time-concentration curve was calculated using the trapezoidal

SUBMITTER: Henriques Ldos S 

PROVIDER: S-EPMC3460023 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature