Dynamics of enhancer chromatin signatures mark the transition from pluripotency to cell specification during embryogenesis.

ABSTRACT: The generation of distinctive cell types that form different tissues and organs requires precise, temporal and spatial control of gene expression. This depends on specific cis-regulatory elements distributed in the noncoding DNA surrounding their target genes. Studies performed on mammalian embryonic stem cells and Drosophila embryos suggest that active enhancers form part of a defined chromatin landscape marked by histone H3 lysine 4 mono-methylation (H3K4me1) and histone H3 lysine 27 acetylation (H3K27ac). Nevertheless, little is known about the dynamics and the potential roles of these marks during vertebrate embryogenesis. Here, we provide genomic maps of H3K4me1/me3 and H3K27ac at four developmental time-points of zebrafish embryogenesis and analyze embryonic enhancer activity. We fin

SUBMITTER: Bogdanovic O 

PROVIDER: S-EPMC3460198 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature