Transethnic meta-analysis of genomewide association studies.

ABSTRACT: The detection of loci contributing effects to complex human traits, and their subsequent fine-mapping for the location of causal variants, remains a considerable challenge for the genetics research community. Meta-analyses of genomewide association studies, primarily ascertained from European-descent populations, have made considerable advances in our understanding of complex trait genetics, although much of their heritability is still unexplained. With the increasing availability of genomewide association data from diverse populations, transethnic meta-analysis may offer an exciting opportunity to increase the power to detect novel complex trait loci and to improve the resolution of fine-mapping of causal variants by leveraging differences in local linkage disequilibrium structure between

SUBMITTER: Morris AP 

PROVIDER: S-EPMC3460225 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature