Effect of PSCA gene polymorphisms on gastric cancer risk and survival prediction: A meta-analysis.

ABSTRACT: Previous studies have shown that two single-nucleotide polymorphisms (SNPs) in PSCA (rs2976392 and rs2294008) are associated with gastric cancer (GC), but the results are conflicting. Additionally, the prognostic value of PSCA gene polymorphisms for GC patients is unknown. We performed a meta-analysis using 9 eligible case-control studies to investigate the association between PSCA polymorphisms and GC risk, and additionally investigated the prognostic value of PSCA polymorphisms for GC patients with two eligible studies. The association was measured using random-effect or fixed-effect odds ratios (ORs) combined with 95% confidence intervals (CIs) according to the heterogeneity of the studies. We found that rs2294008 (dominant model: OR, 1.44; 95% CI, 1.16-1.79) and rs2976392 (dominant mod

SUBMITTER: Zhang T 

PROVIDER: S-EPMC3460280 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature