Transcription factor binding at enhancers: shaping a genomic regulatory landscape in flux.

ABSTRACT: The mammalian genome is packed tightly in the nucleus of the cell. This packing is primarily facilitated by histone proteins and results in an ordered organization of the genome in chromosome territories that can be roughly divided in heterochromatic and euchromatic domains. On top of this organization several distinct gene regulatory elements on the same chromosome or other chromosomes are thought to dynamically communicate via chromatin looping. Advances in genome-wide technologies have revealed the existence of a plethora of these regulatory elements in various eukaryotic genomes. These regulatory elements are defined by particular in vitro assays as promoters, enhancers, insulators, and boundary elements. However, recent studies indicate that the in vivo distinction between these eleme

SUBMITTER: Palstra RJ 

PROVIDER: S-EPMC3460357 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature