Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis.

ABSTRACT: The application of functional genomic analysis of breast cancer metastasis has led to the identification of a growing number of organ-specific metastasis genes, which often function in concert to facilitate different steps of the metastatic cascade. However, the gene regulatory network that controls the expression of these metastasis genes remains largely unknown. Here, we demonstrate a computational approach for the deconvolution of transcriptional networks to discover master regulators of breast cancer bone metastasis. Several known regulators of breast cancer bone metastasis such as Smad4 and HIF1 were identified in our analysis. Experimental validation of the networks revealed BACH1, a basic leucine zipper transcription factor, as the common regulator of several functional metastasis g

SUBMITTER: Liang Y 

PROVIDER: S-EPMC3460454 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature