Formyl peptide receptors from immune and vomeronasal system exhibit distinct agonist properties.

ABSTRACT: The formyl peptide receptor (Fpr) family is well known for its contribution to immune defense against pathogens in human and rodent leukocytes. Recently, several structurally related members of these receptors were discovered in sensory neurons of the mouse vomeronasal organ (VNO), key detectors of pheromones and related semiochemicals. Although the biological role of vomeronasal Fprs is not yet clear, the known contribution of other Fprs to host immune defense suggested that they could contribute to vomeronasal pathogen sensing. Precise knowledge about the agonist properties of mouse Fprs is required to determine their function. We expressed all seven mouse and three human Fprs using an in vitro system and tested their activation with 32 selected compounds by conducting high throughput ca

SUBMITTER: Bufe B 

PROVIDER: S-EPMC3460462 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature