The single-nucleotide resolution transcriptome of Pseudomonas aeruginosa grown in body temperature.

ABSTRACT: One of the hallmarks of opportunistic pathogens is their ability to adjust and respond to a wide range of environmental and host-associated conditions. The human pathogen Pseudomonas aeruginosa has an ability to thrive in a variety of hosts and cause a range of acute and chronic infections in individuals with impaired host defenses or cystic fibrosis. Here we report an in-depth transcriptional profiling of this organism when grown at host-related temperatures. Using RNA-seq of samples from P. aeruginosa grown at 28°C and 37°C we detected genes preferentially expressed at the body temperature of mammalian hosts, suggesting that they play a role during infection. These temperature-induced genes included the type III secretion system (T3SS) genes and effectors, as well as the genes responsibl

SUBMITTER: Wurtzel O 

PROVIDER: S-EPMC3460626 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature