Short read sequence typing (SRST): multi-locus sequence types from short reads.

ABSTRACT:

Background

Multi-locus sequence typing (MLST) has become the gold standard for population analyses of bacterial pathogens. This method focuses on the sequences of a small number of loci (usually seven) to divide the population and is simple, robust and facilitates comparison of results between laboratories and over time. Over the last decade, researchers and population health specialists have invested substantial effort in building up public MLST databases for nearly 100 different bacterial species, and these databases contain a wealth of important information linked to MLST sequence types such as time and place of isolation, host or niche, serotype and even clinical or drug resistance profiles. Recent advances in sequencing technology mean it is increasingly feasible to perform ba

SUBMITTER: Inouye M 

PROVIDER: S-EPMC3460743 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature