A20 (TNFAIP3) alleviates CVB3-induced myocarditis via inhibiting NF-κB signaling.

ABSTRACT:

Background

Viral myocarditis, which is most prevalently caused by Coxsackievirus B3 (CVB3) infection, is a serious clinical condition characterized by cardiac inflammation. However, efficient therapies targeting inflammation are still lacking and much needed. A20, also known as tumor necrosis factor alpha induced protein 3 (TNFAIP3) is a key negative regulator of inflammation. But whether A20 may affect cardiac inflammation during acute viral myocarditis remains to be elucidated. The aim of this study was to investigate the potential protective effect of A20 on CVB3-induced myocarditis.

Methodology/principal findings

Mice were intraperitoneally inoculated with CVB3 to establish acute viral myocarditis model. We found that the expression of pro-inflammatory cytokines, includi

SUBMITTER: Gui J 

PROVIDER: S-EPMC3460927 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature