Comparative analysis of the immunogenicity and protective effects of inactivated EV71 vaccines in mice.

ABSTRACT:

Background

Enterovirus 71 (EV71) is the major causative agent of hand, foot, and mouth disease (HFMD). Three inactivated EV71 whole-virus vaccines of different strains developed by different manufacturers in mainland China have recently entered clinical trials. Although several studies on these vaccines have been published, a study directly comparing the immunogenicity and protective effects among them has not been carried out, which makes evaluating their relative effectiveness difficult. Thus, properly comparing newly developed vaccines has become a priority, especially in China.

Methods and findings

This comparative immunogenicity study was carried out on vaccine strains (both live and inactivated), final container products (FCPs) without adjuvant, and corresponding FCPs

SUBMITTER: Mao Q 

PROVIDER: S-EPMC3460965 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature