WaveSeq: a novel data-driven method of detecting histone modification enrichments using wavelets.

ABSTRACT:

Background

Chromatin immunoprecipitation followed by next-generation sequencing is a genome-wide analysis technique that can be used to detect various epigenetic phenomena such as, transcription factor binding sites and histone modifications. Histone modification profiles can be either punctate or diffuse which makes it difficult to distinguish regions of enrichment from background noise. With the discovery of histone marks having a wide variety of enrichment patterns, there is an urgent need for analysis methods that are robust to various data characteristics and capable of detecting a broad range of enrichment patterns.

Results

To address these challenges we propose WaveSeq, a novel data-driven method of detecting regions of significant enrichment in ChIP-Seq data. Our app

SUBMITTER: Mitra A 

PROVIDER: S-EPMC3461018 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature