Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.

ABSTRACT:

Rationale

Asthma has substantial morbidity and mortality and a strong genetic component, but identification of genetic risk factors is limited by availability of suitable studies.

Objectives

To test if population-based cohorts with self-reported physician-diagnosed asthma and genome-wide association (GWA) data could be used to validate known associations with asthma and identify novel associations.

Methods

The APCAT (Analysis in Population-based Cohorts of Asthma Traits) consortium consists of 1,716 individuals with asthma and 16,888 healthy controls from six European-descent population-based cohorts. We examined associations in APCAT of thirteen variants previously reported as genome-wide significant (P<5 x 10(-8)) and three variants reported as suggestive (P<5× 10(-

SUBMITTER: Ramasamy A 

PROVIDER: S-EPMC3461045 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature