The utility of molecular diagnostics to predict recurrence of head and neck carcinoma.

ABSTRACT:

Background

Locoregional recurrence is the major cause of treatment failure after surgery for oral squamous cell carcinoma. Molecular diagnostics have the potential to improve on clinicopathological parameters to predict this recurrence and plan adjuvant treatment. The test most frequently applied is based on detecting TP53 mutations, but alternative methodology is required for cases that harbour the wild-type gene.

Methods

One hundred and two cases with tumour-adjacent margins, considered to be clear margins by microscopy, were examined using carefully optimised molecular diagnostics based on detection of the TP53 and Ly-6D markers. The markers were also combined to provide a dual approach.

Results

The dual molecular diagnostic identified cases with a significant incr

SUBMITTER: Pena Murillo C 

PROVIDER: S-EPMC3461148 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature