Epigenetic remodelling of gene expression profiles of neoplastic and normal tissues: immunotherapeutic implications.

ABSTRACT:

Background

Epigenetic remodelling of cancer cells is an attractive therapeutic strategy and distinct DNA hypomethylating agents (DHA) are being actively evaluated in patients with hemopoietic or solid tumours. However, no studies have investigated the modulation of gene expression profiles (GEP) induced by DHA in transformed and benign tissues. Such information is mandatory to clarify the fine molecular mechanism(s) underlying the clinical efficacy of DHA, to identify appropriate therapeutic combinations, and to address safety issues related to their demethylating potential in normal tissues. Thus, utilising a syngeneic mouse model, we investigated the remodelling of GEP of neoplastic and normal tissues induced by systemic administration of DHA.

Methods

The murine mammary ca

SUBMITTER: Coral S 

PROVIDER: S-EPMC3461156 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature