The effect of core decompression on local expression of BMP-2, PPAR-γ and bone regeneration in the steroid-induced femoral head osteonecrosis.

ABSTRACT:

Background

To investigate the efficacy of the sole core decompression surgery for the treatment of steroid-induced femoral head osteonecrosis.

Methods

The model was established by administration of steroids in combination with horse serum. The rabbits with bilateral femoral head osteonecrosis were randomly selected to do the one side of core decompression. The other side was used as the sham. Quantitative RT-PCR and western blot techniques were used to measure the local expression of BMP-2 and PPAR-γ. Bone tissues from control and operation groups were histologically analyzed by H&E staining. The comparisons of the local expression of BMP-2 and PPAR-γ and the bone regeneration were further analyzed between different groups at each time point.

Results

The expression of

SUBMITTER: Wang W 

PROVIDER: S-EPMC3461435 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature