Interaction between the BDNF gene Val/66/Met polymorphism and morning cortisol levels as a predictor of depression in adult women.

ABSTRACT:

Background

Common genetic variants, such as the brain-derived neurotrophic factor (BDNF) Val/66/Met polymorphism (rs6265), are known to interact with environmental factors such as early adversity to increase the risk of subsequent major depression. Much less is known about how they interact with individual differences in cortisol, although these also represent a risk for major depression.

Aims

To determine whether this BDNF variant moderated the risk represented by higher levels of morning salivary cortisol in adult women.

Method

We recruited 279 premenopausal women who were at high risk of major depressive disorder because of either negative self-evaluation, unsupportive core relationship or chronic subclinical symptoms of depression or anxiety. Morning salivary cort

SUBMITTER: Herbert J 

PROVIDER: S-EPMC3461447 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature