Significant calendar period deviations in testicular germ cell tumors indicate that postnatal exposures are etiologically relevant.

ABSTRACT:

Purpose

The current working model of type II testicular germ cell tumor (TGCT) pathogenesis states that carcinoma in situ arises during embryogenesis, is a necessary precursor, and always progresses to cancer. An implicit condition of this model is that only in utero exposures affect the development of TGCT in later life. In an age-period-cohort analysis, this working model contends an absence of calendar period deviations. We tested this contention using data from the SEER registries of the United States.

Methods

We assessed age-period-cohort models of TGCTs, seminomas, and nonseminomas for the period 1973-2008. Analyses were restricted to whites diagnosed at ages 15-74 years. We tested whether calendar period deviations were significant in TGCT incidence trends adjusted fo

SUBMITTER: Speaks C 

PROVIDER: S-EPMC3461587 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature