Ascending the nucleosome face: recognition and function of structured domains in the histone H2A-H2B dimer.

ABSTRACT: Research over the past decade has greatly expanded our understanding of the nucleosome's role as a dynamic hub that is specifically recognized by many regulatory proteins involved in transcription, silencing, replication, repair, and chromosome segregation. While many of these nucleosome interactions are mediated by post-translational modifications in the disordered histone tails, it is becoming increasingly apparent that structured regions of the nucleosome, including the histone fold domains, are also recognized by numerous regulatory proteins. This review will focus on the recognition of structured domains in the histone H2A-H2B dimer, including the acidic patch, the H2A docking domain, the H2B α3-αC helices, and the HAR/HBR domains, and will survey the known biological functions of his

SUBMITTER: Wyrick JJ 

PROVIDER: S-EPMC3461831 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature