The pivotal role of integrin β1 in metastasis of head and neck squamous cell carcinoma.

ABSTRACT:

Purpose

This study aimed to understand the prognostic value of integrin β1 expression in head and neck squamous cell carcinoma (HNSCC) and the mechanism underlying its association with metastatic HNSCC.

Experimental design

Archival HNSCC tissues including 99 nonmetastatic primary tumors and 101 metastatic primary tumors were examined for the association of integrin β1 expression with metastasis and disease prognosis by appropriate statistical methods. Fluorescence-activated cell sorting was used to separate the integrin β1(high/+) cell population from the integrin β1(low/-) population in HNSCC cell lines. These two populations and integrin β1 shRNA knockdown HNSCC cells were examined for the effect of integrin β1 on invasion in vitro and on lymph node and lung metastases in

SUBMITTER: Wang D 

PROVIDER: S-EPMC3462074 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature