Phenotypic and genomic analysis of hypervirulent human-associated Bordetella bronchiseptica.

ABSTRACT:

Background

B. bronchiseptica infections are usually associated with wild or domesticated animals, but infrequently with humans. A recent phylogenetic analysis distinguished two distinct B. bronchiseptica subpopulations, designated complexes I and IV. Complex IV isolates appear to have a bias for infecting humans; however, little is known regarding their epidemiology, virulence properties, or comparative genomics.

Results

Here we report a characterization of the virulence of human-associated complex IV B. bronchiseptica strains. In in vitro cytotoxicity assays, complex IV strains showed increased cytotoxicity in comparison to a panel of complex I strains. Some complex IV isolates were remarkably cytotoxic, resulting in LDH release levels in A549 cells that were 10- to 20-fold

SUBMITTER: Ahuja U 

PROVIDER: S-EPMC3462115 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature