Modeling and experimental methods to probe the link between global transcription and spatial organization of chromosomes.

ABSTRACT: Genomes are spatially assembled into chromosome territories (CT) within the nucleus of living cells. Recent evidences have suggested associations between three-dimensional organization of CTs and the active gene clusters within neighboring CTs. These gene clusters are part of signaling networks sharing similar transcription factor or other downstream transcription machineries. Hence, presence of such gene clusters of active signaling networks in a cell type may regulate the spatial organization of chromosomes in the nucleus. However, given the probabilistic nature of chromosome positions and complex transcription factor networks (TFNs), quantitative methods to establish their correlation is lacking. In this paper, we use chromosome positions and gene expression profiles in interphase fibro

SUBMITTER: Iyer KV 

PROVIDER: S-EPMC3462193 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature